The Ocean Surface Mixing, Ocean Sub-mesoscale Interaction Study (OSMOSIS) data set contains a variety of oceanographic measurements including a year long time series of the properties of the ocean surface boundary layer and its controlling 3D physical processes. The core observations include measurements of temperature, salinity, nutrients, currents and shear harvested from a suite of instrumentation including CTDs, ocean gliders, drifter buoys and moored sensors. OSMOSIS data were collected during three cruises. The first cruise undertook preliminary exploratory work in the Clyde Sea (September 2011) to hone techniques and strategies. The following cruises carried out mooring deployments and recovery in the vicinity of the Porcupine Abyssal Plain (PAP) observatory (in late Summer 2012 and 2013 respectively). Additional opportunist ship time being factored in to support the ambitious glider operations associated with OSMOSIS. This multiple year study will combine traditional observational techniques, such as moorings and CTDs, with the latest autonomous sampling technologies (including ocean gliders), capable of delivering near real-time scientific measurements through the water column. The OSMOSIS data set will contain high-resolution vertical measurements, which will shed light on the complex turbulent processes that drive the deepening of the OSBL and similarly the sub-mesoscale processes promoting OSBL re-stratification. Continuous mooring and glider measurements over a complete annual cycle will also provide invaluable insight into how the OSBL evolves over time. The NERC OSMOSIS Consortium brings together scientists from various UK research centres including the University of Southampton School of Ocean and Earth Sciences, University of Reading, Bangor and the National Oceanography Centre (NOC).